Home page


Volume 163 - Anno 2012 - Numero 5

Surgical strategies in patients with medullary thyroid carcinoma

di S. Sorrenti, E. Guaitoli, A. Catania, V. D’Andrea, F. M.Di Matteo, M. Nardi, N. Prinzi, F. Nardi, V. Ascoli, E. Baldini, S. Ulisse, E. De Antoni

Objectives. Aim of the study was to identify, in 59 operated patients affected by medullary thyroid carcinoma (MTC), the recurrence rate, survival, mortality and incidences of surgically derived hypoparathyroidism and recurrent laryngeal nerve injury (RLNI).
Materials and Methods. Based on pre-surgical diagnosis of the 59 patients included in the study, 35 underwent total thyroidectomy with central neck dissection (Group A), 14 total thyroidectomy, central neck dissection and monolateral functional neck dissection (Group B) and 10 total thyroidectomy central neck dissection, bilateral functional neck dissection (Group C). Overall survival, recurrences, incidence of hypoparathyroidism and RLNI were evaluated.
Results. The survival and recurrences were not statistically different among the three Groups. In Group B there was major probability of re-operation (p=0.042). The mortality rate was clearly major in Group C (p=0.003) due to the stage of pathology. Group C showed a high number of hypoparatiroidism compared to Group B, and B compared to A. In Group A there was only one unexpected RLNI; in 5 cases, 3 in Group B and 2 in Group C, there were a necessity laringeal section due to nerve tumor involvement.
Conclusions. From our data it appears clearly that disease outcome following the different surgical approaches is mainly determinated by the stage of the disease at diagnosis. However, the finding that patients in Group A and B showed a high rate of local-regional recurrences may suggest that homolateral lymphadenectomy in Group A patients and bilateral lymphadenectomy in Group B patients should be always performed. Clin Ter 2012; 163(5):e303-306

Visualizza il file PDF

ATTENZIONE: per accedere al servizio di consultazione online dei file pdf occorre essere abbonati alla rivista ed aver abilitato il proprio pin.
Se non siete ancora abbonati potete abbonarvi e ricevere il pin attraverso il nostro online store.
Per l'attivazione del pin ricevuto, contattare ordini@seu-roma.it

Società Editrice Universo s.r.l.
Via G.B.Morgagni, 1 - 00161 Roma - tel (06) 4402054 / (06) 44231171, (06) 64503500 fax (06) 4402033